50 Cent and Estranged Son Roast Each Other on Marquise's 26th Bday

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50 Cent is crushing his son Marquise Jackson's hopes at a reconciliation ... and what makes his latest diss even more cold-blooded is the fact it comes on his son's 26th birthday!!!

The legendary rapper responded to Marquise's on-camera olive branch Thursday with a very personalized dig buried in a promo for his ongoing European tour.

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